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Place the chicken tenders in a bowl with buttermilk, salt, and black pepper. Mix gently, cover, and let them rest for 15 minutes.
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In a separate bowl, combine the flour, paprika, garlic powder, onion powder, cayenne pepper, and salt.
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Remove the chicken from the buttermilk and coat each piece evenly in the flour mixture. Press lightly so the coating sticks well.
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Heat vegetable oil in a deep pan over medium heat. Fry the chicken tenders in batches until golden brown and fully cooked, about 4 to 5 minutes per side. Transfer to a wire rack or paper towel.
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In a small bowl, mix the hot frying oil with cayenne pepper, brown sugar, paprika, and garlic powder until smooth.
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Brush the warm sauce generously over the fried chicken tenders.
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Serve hot on its own or with pickles and bread on the side.